2,525 research outputs found
Greater Greenville Regional Economic Scorecard March 2008
Community/Rural/Urban Development,
Greater Greenville Regional Economic Scorecard, 2009
Community/Rural/Urban Development,
Parenting interventions for ADHD: a systematic literature review and meta-analysis
Objective. To evaluate the evidence base relating to the effectiveness of parent-administered behavioral interventions for ADHD
Temporal reproduction and its neuroanatomical correlates in adults with attention deficit hyperactivity disorder and their unaffected first-degree relatives
Background:
Little is known about time perception, its putative role as cognitive endophenotype, and its neuroanatomical underpinnings in adults with attention deficit hyperactivity disorder (ADHD).
Method:
Twenty adults with ADHD, 20 unaffected first-degree relatives and 20 typically developing controls matched for age and gender undertook structural magnetic resonance imaging scans. Voxel-based morphometry with DARTEL was performed to obtain regional grey-matter volumes. Temporal processing was investigated as a putative cognitive endophenotype using a temporal reproduction paradigm. General linear modelling was employed to examine the relationship between temporal reproduction performances and grey-matter volumes.
Results:
ADHD participants were impaired in temporal reproduction and unaffected first-degree relatives performed in between their ADHD probands and typically developing controls. Increased grey-matter volume in the cerebellum was associated with poorer temporal reproduction performance.
Conclusions:
Adults with ADHD are impaired in time reproduction. Performances of the unaffected first-degree relatives are in between ADHD relatives and controls, suggesting that time reproduction might be a cognitive endophenotype for adult ADHD. The cerebellum is involved in time reproduction and might play a role in driving time performances
Riding a Spiral Wave: Numerical Simulation of Spiral Waves in a Co-Moving Frame of Reference
We describe an approach to numerical simulation of spiral waves dynamics of
large spatial extent, using small computational grids.Comment: 15 pages, 14 figures, as accepted by Phys Rev E 2010/03/2
Helicoidal instability of a scroll vortex in three-dimensional reaction-diffusion systems
We study the dynamics of scroll vortices in excitable reaction-diffusion
systems analytically and numerically. We demonstrate that intrinsic
three-dimensional instability of a straight scroll leads to the formation of
helicoidal structures. This behavior originates from the competition between
the scroll curvature and unstable core dynamics. We show that the obtained
instability persists even beyond the meander core instability of
two-dimensional spiral wave.Comment: 4 pages, 5 figures, revte
Primary Health care as a platform for addressing racial discrimination to “leave no one behind” and reduce health inequities
The health inequities faced by populations experiencing racial discrimination, including indigenous peoples and people of African descent, Roma, and other ethnic minorities, are an issue of global concern. Health systems have an important role to play in tackling these health inequities. Health systems based on comprehensive Primary Health Care (PHC) are best placed to tackle health inequities because PHC encompasses a whole-of-society approach to health. PHC includes actions to address the wider social determinants of health, multisectoral policy and action, intercultural and integrated healthcare services, community empowerment, and a focus on addressing health inequities. PHC can also serve as a platform for introducing specific actions to tackle racial discrimination and can act to drive wider societal change for tackling racial and ethnic health inequities
Computational Study of Turbulent-Laminar Patterns in Couette Flow
Turbulent-laminar patterns near transition are simulated in plane Couette
flow using an extension of the minimal flow unit methodology. Computational
domains are of minimal size in two directions but large in the third. The long
direction can be tilted at any prescribed angle to the streamwise direction.
Three types of patterned states are found and studied: periodic, localized, and
intermittent. These correspond closely to observations in large aspect ratio
experiments.Comment: 4 pages, 5 figure
Coarse-grained model of entropic allostery
Many signaling functions in molecular biology require proteins to bind to substrates such as DNA in response to environmental signals such as the simultaneous binding to a small molecule. Examples are repressor proteins which may transmit information via a conformational change in response to the ligand binding. An alternative entropic mechanism of "allostery" suggests that the inducer ligand changes the intramolecular vibrational entropy, not just the mean static structure. We present a quantitative, coarse-grained model of entropic allostery, which suggests design rules for internal cohesive potentials in proteins employing this effect. It also addresses the issue of how the signal information to bind or unbind is transmitted through the protein. The model may be applicable to a wide range of repressors and also to signaling in trans-membrane proteins
Scroll waves in isotropic excitable media : linear instabilities, bifurcations and restabilized states
Scroll waves are three-dimensional analogs of spiral waves. The linear
stability spectrum of untwisted and twisted scroll waves is computed for a
two-variable reaction-diffusion model of an excitable medium. Different bands
of modes are seen to be unstable in different regions of parameter space. The
corresponding bifurcations and bifurcated states are characterized by
performing direct numerical simulations. In addition, computations of the
adjoint linear stability operator eigenmodes are also performed and serve to
obtain a number of matrix elements characterizing the long-wavelength
deformations of scroll waves.Comment: 30 pages 16 figures, submitted to Phys. Rev.
- …